137171-80-3Relevant academic research and scientific papers
ANTIBACTERIAL COMPOSITIONS
-
, (2018/01/19)
Pharmaceutical composition comprising beta-lactamase inhibitors or a pharmaceutically acceptable salt, and a compound of Formula (I) or a pharmaceutically acceptable salt thereof are disclosed.
A novel series of parenteral cephalosporins exhibiting potent activities against Pseudomonas aeruginosa and other Gram-negative pathogens: Synthesis and structure-activity relationships
Yamawaki, Kenji,Nomura, Takashi,Yasukata, Tatsuro,Uotani, Koichi,Miwa, Hideaki,Takeda, Kei,Nishitani, Yasuhiro
, p. 6716 - 6732 (2008/03/28)
A series of 7β-[2-(2-aminothiazol-4-yl)-2-(Z)-(carboxymethoxyimino)acetamido]cephalosporins bearing a 1-(substituted)-1H-pyrrolo[3,2-b]pyridinium group at C-3′ position was synthesized and their in vitro antibacterial activities against Pseudomonas aeruginosa and other Gram-negative pathogens were evaluated. Among the cephalosporins prepared, 7β-[2-(2-amino-5-chlorothiazol-4yl)-2(Z)-((S)-1-carboxyethoxyimino)acetamido]cephalosporins (42d) showed potent antibacterial activities against P. aeruginosa and other Gram-negative pathogens including the strains which produce class C β-lactamase and extended spectrum β-lactamase (ESBL). These results imply that both the Cl atom on the C-7 aminothiazole moiety and the α-substituent at the iminoether moiety are essential for the stability against β-lactamase and the potent activity against Gram-negative bacteria including P. aeruginosa.
