137172-05-5Relevant academic research and scientific papers
Citrusosides A-D and furanocoumarins with cholinesterase inhibitory activity from the fruit peels of citrus hystrix
Youkwan, Juthamanee,Sutthivaiyakit, Somyote,Sutthivaiyakit, Pakawadee
, p. 1879 - 1883 (2010)
Four new compounds, citrusosides A-D (1-4), and 15 known compounds were isolated from the hexanes and CH2Cl2 extracts of the peels of Citrus hystrix fruits. Compound 1 is a 1-O-isopropyl-6-O-β-d- glucopyranosyl ester of 5″,9″-dimethyl-2″,8″-decadienoic acid. Compounds 2-4 possess a 1-O-isopropyl-β-d-glucopyranosyl and a dihydroxyprenylfuranocoumarin moiety conjugated to the 3-hydroxy-3- methylglutaric acid as diesters. Several furanocoumarins were evaluated for their cholinesterase inhibitory activity. (R)-(+)-6′-Hydroxy-7′- methoxybergamottin, (R)-(+)-6′,7′-dihydroxybergamottin, and (+)-isoimparatorin showed IC50 values of 11.2 ± 0.1, 15.4 ± 0.3, and 23 ± 0.2 μM, respectively. Bioassay results indicated that the presence of a dioxygenated geranyl chain in the test compounds is crucial for the inhibitory activity.
