137186-46-0Relevant academic research and scientific papers
Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
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, (2011/07/06)
This invention relates to tri- and tetra-substituted-oxetanes, e.g. (±)-cis- and (±)-trans-2-[(4-(4-isopropylpiperazin-1-yl)phenoxy)methyl]-4-(2,4-dihalophenyl)-4-[1H-1,2,4-triazol-1-yl)-methyl]oxetane and tri- and tetra-substituted-tetrahydrofurans, e.g. (±)-cis- and (±)-trans-1-[4-[[2-(2,4-dihalophenyl)tetrahydro-2-[(1H-azol-1-yl)methyl]-5-furanylmethoxy]phenyl]-4-yl-1-substituted piperazine-3-one and related derivatives which exhibit antifungal and antiallergy activities, pharmaceutical composition thereof, methods of their use in treating or preventing susceptible fungal infections and allergic reactions in a host including warm-blooded animals such as humans.
Tri- and tetra-substituted-oxetanes and -tetrahydrofurans and intermediates thereof
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, (2008/06/13)
This invention relates to tri- and tetra--substituted-oxetanes of the formula,e.g. (±)-cis- and (±)-trans-2-[(4--(4-isopropylpiperazin-1-yl)phenoxy)methyl]-4-(2,4--dihalophenyl)-4-[1H-1,2,4-triazol-1-yl)methyl]oxetane and tri- and tetra- substituted-tetrahydrofurans, e.g. (±)--cis- and (±)-trans-1-[4-[[2-(2,4-dihalophenyl)tetrahydro--2-[(1H-azol-1-yl)methyl]-5-furanyl]methoxy]phenyl]-4-yl--1-substituted piperazine-3-one and related derivatives which exhibit antifungal and antiallergy activities, pharmaceutical composition thereof, methods of their use in treating or preventing susceptible fungal infections and allergic reactions in a host including warm-blooded animals such as humans.
