137197-01-4

Upstream product

• 93679-30-2 Z-CysHisOMe 
• 107-13-1 acrylonitrile 
• 17607-25-9 (S)-2-(2-Benzyloxycarbonylamino-3-{2-benzyloxycarbonylamino-2-[(S)-2-(1H-imidazol-4-yl)-1-methoxycarbonyl-ethylcarbamoyl]-ethyldisulfanyl}-propionylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester 
• 93679-30-2 N-Z-Cysteinyl histidine methyl ester 
• 6968-11-2 N,N'-bis(benzyloxycarbonyl)-L-cystine 
• 645-35-2 L-histidine monohydrochloride 
• 501-53-1 benzyl chloroformate 
• 17607-25-9 Bis-N-benzyloxycarbonyl cystinyl di-histidine methyl ester 
• 13961-95-0 Bis-N-benzyloxycarbonyl cystine di p-nitrophenyl ester 
• 7389-87-9 L-histidine methyl ester dihydrochloride 

Relevant academic research and scientific papers

Synthesis of " zinc finger " template

The zinc finger template brings about protein-DNA recognition. The first synthesis of a metal template which incorporates the essential features of the zinc finger motif and represented by structure (a) has been achieved from the key tripeptide bis-N-benzyloxycarbonyl cystinyl di-histidine methyl ester (2) using a novel thiol-disulfide exchange and subsequent complexation. The cobalt motif (5) has been similarly prepared. FAB mass spectrum 1D nmr COSY and NOESY spectra, difference NOe of (1) and the UV of (5) are in very good agreement with a ligand distribution profile around the central tetrahedral metal ion similar to that deduced for natural and synthetic zinc finger proteins. The potential of (1) or its appropriate variants in the understanding of diverse facets of DNA recognition is discussed.

Highly Efficient Propane-1,3-dithiol Mediated Thiol-disulphide Interchange: a Facile and Clean Methodology for S-S Reduction in Peptides

Propane-1,3-dithiol, at room temperature and in the absence of any promoter, neatly brings about the S-S -> 2SH change, and the latter can be isolated as acrylonitrile adducts; the methodology has been tested with several substrates including c-lysozyme, insulin and oxytocin, and spontaneous imidazole promoted S-deprotection was observed in the case of Z-Cys(S-CH2CH2CN)His-OMe.