137197-02-5Relevant academic research and scientific papers
Highly Efficient Propane-1,3-dithiol Mediated Thiol-disulphide Interchange: a Facile and Clean Methodology for S-S Reduction in Peptides
Ranganathan, Subramania,Jayaraman, Narayanaswamy
, p. 934 - 936 (1991)
Propane-1,3-dithiol, at room temperature and in the absence of any promoter, neatly brings about the S-S -> 2SH change, and the latter can be isolated as acrylonitrile adducts; the methodology has been tested with several substrates including c-lysozyme, insulin and oxytocin, and spontaneous imidazole promoted S-deprotection was observed in the case of Z-Cys(S-CH2CH2CN)His-OMe.
