137206-91-8

Usage

Type of compound

Indole derivative

Functional group

Carboxaldehyde

Substituent

Methyl

Usage

Research and development applications

Versatility

Intermediate for the synthesis of various pharmaceuticals and agrochemicals

Biological and pharmacological activities

Anti-inflammatory and antimicrobial properties

Structure and reactivity

Unique, valuable building block for the synthesis of diverse organic molecules

Role in scientific research

Valuable tool for the development of new medicinal compounds and bioactive molecules

Upstream product

• 51358-08-8 1-methyl-2-(4-methylphenyl)indole 
• 68-12-2 N,N-dimethyl-formamide 
• 1308865-96-4 2-iodo-N-methyl-N-(4-methylbenzyl)aniline 
• 615-43-0 2-iodophenylamine 
• 104-87-0 4-methyl-benzaldehyde 
• 1040308-59-5 2-iodo-N-(4-methylbenzyl)aniline 
• 68945-00-6 2?p?tolyl?1H?indole?3?carbaldehyde 
• 74-88-4 methyl iodide 
• 55577-25-8 2-(4-methylphenyl)-1H-indole 
• 1364521-87-8 C₁₇H₁₅NO 

Downstream Products

• 136581-60-7 N-phenyl-2-<methylene> hydrazinecarbothiamide 
• 83958-18-3 3-Ethyl-2-[(Z)-2-(1-methyl-2-p-tolyl-1H-indol-3-yl)-vinyl]-6-selenocyanato-benzothiazol-3-ium; bromide 
• 83958-22-9 3-Ethyl-2-[(Z)-2-(1-methyl-2-p-tolyl-1H-indol-3-yl)-vinyl]-6-nitro-benzothiazol-3-ium; bromide 
• 136581-63-0 3-phenyl-4-oxothiazolin-2-yl hydrazone 
• 137206-89-4 4-oxothiazolin-2-yl hydrazone 

Relevant academic research and scientific papers

Access to Polycyclic Sulfonyl Indolines via Fe(II)-Catalyzed or UV-Driven Formal [2 + 2 + 1] Cyclization Reactions of N-((1H-indol-3-yl)methyl)propiolamides with NaHSO3

A variety of structurally novel polycyclic sulfonyl indolines have been synthesized via FeCl2-catalyzed or UV-driven intramolecular formal [2 + 2 + 1] dearomatizing cyclization reactions of N-(1H-indol-3-yl)methyl)propiolamides with NaHSO3 in an aqueous medium. The reactions involve the formation of one C-C bond and two C-S bonds in a single step.

A N - alkyl - 2 - aryl - indole - 3 - aldehyde synthesis method

The invention discloses a synthetic method for N-alkyl-2-aryl-indol-3-al and belongs to the technical field of chemical pharmacy and fine chemical preparation. Polysubstituted functionalized indole is an important organic compound. Metal-catalyzed sulfonyl triazole is decomposed into metal carbine, and the metal carbine produces a C-H bond insertion reaction for cyclization to obtain N-alkyl-2-aryl-indol-3-al, that is to say, a 1,2,3-trisubstituted indole structure. The method realizes effective synthesis of high-added-value cyclopropylazacyclo, provides a new technological route for preparing polysubstituted indole derivatives and can be widely applied to the field of chemical pharmacy and fine chemical engineering.

An efficient approach to 1,2,3-trisubstituted indole via rhodium catalyzed carbene Csp3-H bond insertion

A method for convenient synthesis of N-alkyl-2-aryl-indole-3-carbaldehyde has been described. A variety of highly valuable indolyl aldehydes have been prepared through this method. Electron donating groups on both aromatic rings (anilinyl and benzyl) facilitate the formation of the desired products. A benzylic C-H insertion by rhodium carbene is the key step for this transformation. This journal is

Ruthenium-catalyzed annulation of alkynes with amides via formyl translocation

The first example of Ru-catalyzed intramolecular annulation of alkynes with amides via formyl translocation has been developed, which provides an efficient approach for the synthesis of 1H-indole-3-carbaldehydes. The Royal Society of Chemistry 2012.

Direct transformation of N, N -dimethylformamide to -CN: Pd-catalyzed cyanation of heteroarenes via C-H functionalization

This paper describes the direct cyanation of indoles and benzofurans employing N,N-dimethylformamide (DMF) as both reagent and solvent. Isotopic labeling experiments indicated that both the N and the C of the cyano group derived from DMF. This transformation offers an alternative method for preparing aryl nitriles, though it is currently limited in scope to indoles and benzofurans.