1372114-40-3Relevant academic research and scientific papers
Reductive ring cleavage of nonconjugated Δ2-isoxazolines to β-hydroxy ketones with aluminum and copper(II) chloride
Karpaviiene, Ieva,Lapinskaite, Ringailé,Bruktus, Algirdas,Cikotiene, Inga
, p. 381 - 384 (2012)
A facile, economic, and efficient protocol for the reduction of nonconjugated Δ2-isoxazolines to the corresponding β-hydroxy ketones using Al/CuCl2 as the reducing agent has been developed. The method is both rapid and complete requiring less than ten minutes to attain total ring cleavage. This is the first example of using an in situ prepared Al/Cu couple in organic synthesis. Georg Thieme Verlag Stuttgart · New York.
