1372129-04-8Relevant articles and documents
Asymmetric total synthesis and absolute stereochemistry of the neuroactive marine macrolide palmyrolide A
Tello-Aburto, Rodolfo,Johnson, Emily M.,Valdez, Cheyenne K.,Maio, William A.
, p. 2150 - 2153 (2012)
The first asymmetric total synthesis and determination of the absolute configuration for the neuroactive marine macrolide palmyrolide A is described. The highlight of the synthesis is macrocyclization via trans-enamide formation catalyzed by copper(I) iodide and cesium carbonate. Comparison with the authentic spectral data confirms the synthesis of (+)-ent-palmyrolide A.
Evolution of a protecting-group-free total synthesis: Studies en route to the neuroactive marine macrolide (-)-palmyrolide A
Tello-Aburto, Rodolfo,Newar, Tara D.,Maio, William A.
experimental part, p. 6271 - 6289 (2012/09/22)
A full account of our synthetic work toward the first total synthesis of the neuroactive marine macrolide (-)-palmyrolide A is described. Our first-generation approach aimed to unlock the unknown C(5)-C(7) stereochemical relationship via the synthesis of