1372151-51-3Relevant academic research and scientific papers
INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
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Paragraph 0343, (2016/01/29)
no abstract published
INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
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, (2013/05/21)
The present invention provides compounds of Formula I I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.
Discovery of selective small molecule ROMK inhibitors as potential new mechanism diuretics
Tang, Haifeng,Walsh, Shawn P.,Yan, Yan,De Jesus, Reynalda K.,Shahripour, Aurash,Teumelsan, Nardos,Zhu, Yuping,Ha, Sookhee,Owens, Karen A.,Thomas-Fowlkes, Brande S.,Felix, John P.,Liu, Jessica,Kohler, Martin,Priest, Birgit T.,Bailey, Timothy,Brochu, Richard,Alonso-Galicia, Magdalena,Kaczorowski, Gregory J.,Roy, Sophie,Yang, Lihu,Mills, Sander G.,Garcia, Maria L.,Pasternak, Alexander
, p. 367 - 372 (2012/06/29)
The renal outer medullary potassium channel (ROMK or Kir1.1) is a putative drug target for a novel class of diuretics that could be used for the treatment of hypertension and edematous states such as heart failure. An internal high-throughput s
