1372151-68-2

Basic information

• Product Name: N2-(1-ethoxyethylidene)-α-mercapto-β-phenylpropionic acid hydrazide
• Synonyms: N2-(1-ethoxyethylidene)-α-mercapto-β-phenylpropionic acid hydrazide
• CAS NO: 1372151-68-2
• Molecular Weight: 266.364
• Mol File: 1372151-68-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N2-(1-ethoxyethylidene)-α-mercapto-β-phenylpropionic acid hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: N2-(1-ethoxyethylidene)-α-mercapto-β-phenylpropionic acid hydrazide(1372151-68-2)
• EPA Substance Registry System: N2-(1-ethoxyethylidene)-α-mercapto-β-phenylpropionic acid hydrazide(1372151-68-2)

Safety Data

• Hazardous Substances Data: 1372151-68-2(Hazardous Substances Data)

Upstream product

• 103499-59-8 methyl α-mercapto-β-phenylpropionate 
• 72772-24-8 S(+)-2-mercapto-3-phenylpropionic acid 
• 150-30-1 Phenylalanine 
• 16503-53-0 2-bromo-3-phenylpropanoic acid 
• 1372151-53-5 α-mercapto-β-phenylpropionic acid hydrazide 
• 78-39-7 Triethyl orthoacetate 

Downstream Products

• 1372151-55-7 6-benzyl-2-methyl-1,3,4-thiadiazin-5(6H)-one 
• 1372151-58-0 2-(1-mercapto-2-phenylethyl)-5-methyl-1,3,4-oxadiazole 

Relevant articles and documents

Reactions of α-mercaptocarboxylic acid hydrazides with triethyl orthoesters: Synthesis of 1,3,4-thiadiazin-5(6H)-ones and 1,3,4-oxadiazoles

Reactions of α-mercapto-β-phenylpropionic and α-mercaptophenylacetic acid hydrazides with triethyl orthoesters were conducted under N2 in glacial acetic acid and resulted in the formation of two groups of products, derivatives of 1,3,4-thiadiazin-5(6H)-ones and 2-(1-mercaptomethyl)-1,3,4-oxadiazoles. When conducting the same transformations on α-mercaptophenylacetic acid hydrazide in the presence of air, two different products from the 1,3,4-oxadiazole family, the appropriate bis(1,3,4-oxadiazol-2-yl-phenylmethyl) disulfides and 2-benzyl-1,3,4- oxadiazoles, were formed with the liberation of free sulfur. The oxygenated bis(1,3,4-oxadiazol-2-yl-phenylmethyl) disulfides were reduced to the corresponding 2-(1-mercaptomethyl)-1,3,4-oxadiazoles with the use of zinc powder under mild conditions.