1372163-84-2

Upstream product

• 1372163-82-0 3-acetoxy-11β-[4-(2-dimethylamino-ethoxy)-phenyl]-estra-1,3,5(10)-triene-17-one 
• 1372163-83-1 11β-[4-(2-methylamino-ethoxy)-phenyl]-estra-1,3,5(10)-triene-3,17β-diol 
• 168640-82-2 11-azido-3,6,9-trioxa-undecanyl p-toluenesulfonate 
• 37860-51-8 tetraethylene glycol di(p-toluenesulfonate) 
• 39931-88-9 (5'R,10'R,13'S)-13'-methyl-1',2',6',7',8',12',13',14',15',16'-decahydro-17'H-spiro[1,3-dioxolane-2,3'-[5,10]epoxycyclopenta[a]phenanthren]-17'-one 
• 5571-36-8 ethylene deltenone 
• 134414-14-5 11beta-(4-hydroxyphenyl)-estra-4,9-diene-3,17-dione 
• 786698-67-7 3-(ethylenedioxy)estra-5,10-epoxy-9⁽¹¹⁾-ene-17-one 
• 106-41-2 4-bromo-phenol 
• 2474-07-9 [2-(4-bromophenoxy)ethyl]dimethylamine 

Relevant academic research and scientific papers

ESTROGEN RECEPTOR IMAGING AGENTS

Compounds useful for molecular imaging of cells expressing estrogen receptors are provided. Also provided are intermediates for making the compounds and methods of making the compounds using a modular convergent strategy. Further, methods of making the intermediates are described, as well as methods of diagnosing disease in a subject by using the compounds as imaging agents.

Design, synthesis, and initial biological evaluation of a steroidal anti-estrogen - Doxorubicin bioconjugate for targeting estrogen receptor-positive breast cancer cells

As part of our program to develop breast cancer specific therapeutic agents, we have synthesized a conjugate agent that is a conjugate of the steroidal anti-estrogen and the potent cytotoxin doxorubicin. In this effort, we employed a modular assembly appr