1372202-92-0Relevant articles and documents
P(O)R2-directed Pd-catalyzed C-H functionalization of biaryl derivatives to synthesize chiral phosphorous ligands
Hu, Rong-Bin,Wang, Hong-Li,Zhang, Hong-Yu,Zhang, Heng,Ma, Yan-Na,Yang, Shang-Dong
, p. 2071 - 2076 (2014)
Chiral phosphorus ligands have been widely used in transition metal-catalyzed asymmetric reactions. Herein, we report a new synthesis approach of chiral biaryls containing a phosphorus moiety using P(O)R 2-directed Pd-catalyzed C-H activation; the functionalized products are produced with good enantioselectivity.
Synthesis of Chiral-Bridged Atropisomeric Monophosphine Ligands with Tunable Dihedral Angles and their Applications in Asymmetric Suzuki–Miyaura Coupling Reactions
Xia, Wang,Li, Yongsu,Zhou, Zihong,Chen, Huixuan,Liang, Hao,Yu, Sifan,He, Xuefeng,Zhang, Yaqi,Pang, Jiyan,Zhou, Zhongyuan,Qiu, Liqin
supporting information, p. 1656 - 1662 (2017/05/22)
Precise chiral recognition was firstly realized in the construction of diastereomeric biaryl monophosphines by means of the substrate-directed asymmetric annulation reactions. A series of new chiral-bridged atropisomeric biphenyl monophosphine ligands with tunable dihedral angles was accordingly synthesized successfully without a resolution step being needed. Using these ligands, different kinds of axially chiral 1,1′-biaryl-2-phosphonates including the first reported quinolyl biaryl phosphonates were prepared in 42–97% yields with up to 96% ee via palladium-catalyzed asymmetric Suzuki coupling reactions. (Figure presented.).
Highly efficient synthesis of a class of novel chiral-bridged atropisomeric monophosphine ligands via simple desymmetrization and their applications in asymmetric suzuki-miyaura coupling reaction
Wang, Shouliang,Li, Jinjin,Miao, Tingting,Wu, Wenhao,Li, Qing,Zhuang, Yue,Zhou, Zhongyuan,Qiu, Liqin
supporting information; experimental part, p. 1966 - 1969 (2012/06/04)
A series of novel chiral-bridged atropisomeric monophosphine ligands were synthesized via convenient and simple pathways. The prepared ligands, especially for ligand 7d, were found to be highly effective in the Pd-catalyzed Suzuki-Miyaura coupling reactio
