137225-05-9 Usage
Uses
Used in Organic Synthesis:
2-(phenylamino)isonicotinonitrile is used as a key intermediate in the synthesis of various organic compounds due to its unique structural features and reactivity. Its presence in the molecule allows for the formation of diverse chemical entities through various synthetic routes.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 2-(phenylamino)isonicotinonitrile is employed as a building block for the development of bioactive compounds. Its structural attributes and potential pharmacological activities make it a promising candidate for the design and synthesis of novel therapeutic agents.
Used in Antitubercular Drug Development:
2-(phenylamino)isonicotinonitrile has been investigated for its potential as an antitubercular agent. Its structural similarity to isoniazid, a well-established antitubercular drug, has sparked interest in exploring its efficacy against Mycobacterium tuberculosis, the causative agent of tuberculosis.
Check Digit Verification of cas no
The CAS Registry Mumber 137225-05-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,7,2,2 and 5 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 137225-05:
(8*1)+(7*3)+(6*7)+(5*2)+(4*2)+(3*5)+(2*0)+(1*5)=109
109 % 10 = 9
So 137225-05-9 is a valid CAS Registry Number.
137225-05-9Relevant academic research and scientific papers
Efficient synthesis of 2-arylamino substituted pyridinyl nitriles by Buchwald-Hartwig amination
Guo, Shuo,Wang, Yaping,Sun, Chunxia,Li, Jingya,Zou, Dapeng,Wu, Yangjie,Wu, Yusheng
supporting information, p. 3233 - 3237 (2013/06/27)
Both nitrile and arylamino groups containing pyridine derivatives are synthesized from commercially available nitrile substituted pyridyl chlorides via a palladium-BINAP catalyst (the second generation catalyst for the amination) in moderate to good yields. The mild conditions permit the presence of base sensitive functional groups. Noteably, the halogen atoms linked to the aromatic ring were maintained in the structures of the products under the amination reaction conditions.
Photochemically Induced Electron Transfer from Aniline Derivatives to Pyridine-2,4-dicarbonitrile: Synthetic and Mechanistic Aspects
Bernardi, Rosanna,Caronna, Tullio,Morrocchi, Sergio,Vittimberga, Bruno M.
, p. 1411 - 1415 (2007/10/02)
A study on the photochemically induced electron transfer from substituted aniline donors to a 2,4-dicyanopyridine acceptor permits the synthesis of new amino derivatives of the pyridine and forms the basis of a hypothesis on the mechanism of the reaction and the influence of the substituent on the aniline ring.
