137226-55-2Relevant academic research and scientific papers
Highly Potent, Orally Active Diester Macrocyclic Human Renin Inhibitors
Weber, Ann E.,Steiner, Mark G.,Krieter, Philip A.,Colletti, Adria E.,Tata, James R.,et al.
, p. 3755 - 3773 (2007/10/02)
Replacing one amide bond in macrocyclic renin inhibitors of the general structure 1 and 2 with an ester linkage gave glutamate-derived inhibitors 3 and serine-derived inhibitors 4.While this oxygen-for-nitrogen exchange had little effect on potency in the
