137252-91-6Relevant academic research and scientific papers
Aminohydroxylation of divinylcarbinol and its application to the synthesis of bicyclic hydroxypyrrolidine and aminotetrahydrofuran building blocks
Caletkova, Olga,Durisova, Diana,Gracza, Tibor,Pronayova, Nada
, p. 66 - 75,10 (2020/08/24)
Aminohydroxylation of prochiral divinylcarbinol and subsequent Pd(II)-catalysed oxy-/amidocarbonylation of aminopentenediols is reported. The method was applied to the preparation of useful building blocks for syntheses of cytotoxic jaspines and glycosidase inhibitor DLX-homologues. The key intermediates, tetrahydrofuranolactones (l-arabino-II) and pyrrolidinolactones (l-arabino-IX and l-xylo-IX), were prepared in a short 2-step sequence from divinylcarbinol.
Controlled Synthesis of Enantio-, Regio-, and Diastereomers of Amino-4-pentenediols from 1,4-Pentadien-ol via Epoxy-4-pentenols I. erythro-1-Amino-4-pentene-2,3-diols
Jaeger, Volker,Huemmer, Walter,Stahl, Ulrich,Gracza, Tibor
, p. 769 - 776 (2007/10/02)
erythro-1-Amino-4-pentene-2,3-diols 7, 8 of both the L- and D-series are readily accessible in high purity from 1,4-pentadien-3-ol via the 1,2-epoxy-4-pentenols 2, 4 by treatment with ammonia, primary aliphatic or aromatic amines, secondary aliphatic or a
