1372552-76-5

Basic information

• Product Name: 5,5'-benzene-1,4-diylbis(1-amino-1H-1,2,4-triazole-3-thiol)
• Synonyms: 5,5'-benzene-1,4-diylbis(1-amino-1H-1,2,4-triazole-3-thiol)
• CAS NO: 1372552-76-5
• Molecular Weight: 306.375
• Mol File: 1372552-76-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,5'-benzene-1,4-diylbis(1-amino-1H-1,2,4-triazole-3-thiol)(CAS DataBase Reference)
• NIST Chemistry Reference: 5,5'-benzene-1,4-diylbis(1-amino-1H-1,2,4-triazole-3-thiol)(1372552-76-5)
• EPA Substance Registry System: 5,5'-benzene-1,4-diylbis(1-amino-1H-1,2,4-triazole-3-thiol)(1372552-76-5)

Safety Data

• Hazardous Substances Data: 1372552-76-5(Hazardous Substances Data)

Upstream product

• 120-61-6 1,4-benzenedicarboxylic acid dimethyl ester 
• 100-21-0 terephthalic acid 
• 81273-25-8 5,5'-benzene-1,4-diylbis(1,3,4-oxadiazole-2-thione) 
• 136-64-1 terephthalohydrazide 

Relevant articles and documents

Synthesis and antibacterial activity of some 5,5'-(1,4-phenylene)-bis-1,3, 4-oxadiazole and bis-1,2,4-triazole derivatives as precursors of new S-nucleosides

Five compounds, namely 5,5'-benzene-1,4-diylbis(1,3,4-oxadiazole-2-thiol)6 and 5,5'-benzene-1,4-diylbis(1H-1,2,4-triazole-3-thiol) 7a and its derivatives 7b-d were synthesized. Two related S-nucleosides 9 and 10 have been prepared from 6 and 7a. Some of these synthesized compounds were tested in vitro by spotting on Mueller Hinton Agar medium against some Gram-positive bacteria, Staphylococcus aureus and Enterococcus faecalis and three Gram-negative bacteria Escherichia coli, Pseudomonasaeruginosa, Pseudomonas fluorescens and compared with the known antibiotics cephalosporin (cefotaxim) and gentamycin. Compound 6 showed significant inhibitory activity against Gram-positive E. faecalis and Gram-negative E. coli bacteria while the others have shown variable inhibition activity.