13726-84-6

Basic information

• Product Name: N-tert-Butoxycarbonyl-L-glutamic acid gamma-tert-butyl ester
• Synonyms: N-ALPHA-T-BOC-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER;N-ALPHA-TERT-BUTYLOXYCARBONYL-L-GLUTAMIC ACID-GAMMA-TERT-BUTYL ESTER;N-ALPHA-T-BUTOXYCARBONYL-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER;N-T-BOC-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER;N-TERT-BUTOXYCARBONYL-L-GLUTAMIC ACID GAMMA-TERT-BUTYL ESTER;BOC-GLU(OBUT)-OH;BOC-GLUTAMIC ACID(OTBU)-OH;BOC-GLU(OTBU)-OH
• CAS NO: 13726-84-6
• Molecular Formula: C₁₄H₂₅NO₆
• Molecular Weight: 303.35
• Product Categories: Amino Acid Derivatives;Amino Acids;Glutamic acid [Glu, E];Boc-Amino Acids and Derivative;Boc-Amino acid series
• Mol File: 13726-84-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 102-105 °C
• Boiling Point: 449.8 °C at 760 mmHg
• Flash Point: 225.8 °C
• Appearance: /
• Density: 1.121 g/cm³
• Vapor Pressure: 2.42E-09mmHg at 25°C
• Refractive Index: 1.47
• Storage Temp.: 2-8°C
• PKA: 3.82±0.10(Predicted)
• BRN: 2149791
• CAS DataBase Reference: N-tert-Butoxycarbonyl-L-glutamic acid gamma-tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-tert-Butoxycarbonyl-L-glutamic acid gamma-tert-butyl ester(13726-84-6)
• EPA Substance Registry System: N-tert-Butoxycarbonyl-L-glutamic acid gamma-tert-butyl ester(13726-84-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 13726-84-6(Hazardous Substances Data)

Usage

Chemical Properties

White powder crystal

InChI:InChI=1/C14H25NO6/c1-13(2,3)20-10(16)8-7-9(11(17)18)15-12(19)21-14(4,5)6/h9H,7-8H2,1-6H3,(H,15,19)(H,17,18)/t9-/m0/s1

Upstream product

• 129016-14-4 (E)-(R)-4-tert-Butoxycarbonylamino-5-hydroxy-pent-2-enoic acid tert-butyl ester 
• 129016-13-3 ((1S,2R,3S,4R)-2,3,4,5-Tetrahydroxy-1-hydroxymethyl-pentyl)-carbamic acid tert-butyl ester 
• 91103-36-5 N-tert.-butyloxycarbonyl-L-serinal 
• 24424-99-5 di-tert-butyl dicarbonate 
• 130333-58-3 1,1-dimethylethyl (4R)-4-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-5-hydroxypentanoate 
• 98102-32-0 (S)-1-benzyl 5-tert-butyl 2-aminopentanedioate hydrochloride 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 2419-56-9 L-glutamic acid 5-tert-butyl ester 
• 910908-09-7 tert.-Butyloxycarbonyl-L-glutaminsaeure-α-benzylester-γ-tert.-butylester 
• 16965-08-5 1,1-dimethylethyl 2,4,5-trichlorophenyl carbonate 
• 2419-94-5 Boc-Glu 

Downstream Products

• 245683-54-9 o-(Boc-Glu(OtBu)-NH)-Ph-NHCO-Ser(OtBu)-Leu-Val-OtBu 
• 245683-60-7 p-(Boc-Glu(OtBu)-NH)-Ph-NHCO-Ser(OtBu)-Leu-Val-OtBu 
• 245683-57-2 m-(Boc-Glu(OtBu)-NH)-Ph-NHCO-Ser(OtBu)-Leu-Val-OtBu 
• 1078723-92-8 tert-butyl 4-(tert-butoxycarbonylamino)-5-(2-(2-fluorobenzoyl)phenylamino)-5-oxopentanoate 
• 66575-26-6 (R)-iso-glutamine t-butyl ester hydrochloride 
• 917926-33-1 Boc-Glu(OtBu)-Pro-OH 

Relevant articles and documents

Novel Dipeptides incorporating selenoamino acids with enhanced bioavailability- Synthesis, pharmaceutical and cosmeceutical applications thereof

Disclosed is a novel synthetic method for isomeric peptides through an appropriate linkage of L-selenomethionine or Se-Methyl-L-selenocysteine with L-glutamic acid. The novel synthetic method produces isomeric peptides of L-selenomethionine or Se-Methyl-L-selenocysteine that exhibit (i) enhanced water solubility; (ii) enhanced rate of dissolution in water; (iii) enhanced bioavailability; (iv) excellent vascular endothelial growth factor promoting activity; (v) excellent anti-5-alpha-reductase activity; (vi) capabilities to prevent/reduce “hair fall” and promote “hair growth”, thereby maintaining a perfect homeostasis for “hair care”. Cosmeceutical and pharmaceutical compositions comprising the isomeric peptides obtained through an appropriate linkage of L-selenomethionine or Se-Methyl-L-selenocysteine with L-glutamic acid are also disclosed. Other dipeptides with several other amino acids and uses thereof are also disclosed.