1372625-22-3Relevant academic research and scientific papers
Alkynoxy-directed C-H functionalizations: Palladium(0)-catalyzed annulations of alkynyl aryl ethers with alkynes
Minami, Yasunori,Shiraishi, Yuki,Kodama, Tatsuro,Kanda, Mayuko,Yamada, Kotomi,Anami, Tomohiro,Hiyama, Tamejiro
, p. 1388 - 1403 (2015/11/16)
Palladium(0)-catalyzed insertion/annulation sequence between aryl silylethynyl ethers and internal alkynes was found to proceed through activation of ortho-C-H bonds assisted by alkynoxy groups and gave stereoselectively (Z)-2-silylmethylenechromenes. The
Palladium-catalyzed cycloaddition of alkynyl aryl ethers with internal alkynes via selective ortho C-H activation
Minami, Yasunori,Shiraishi, Yuki,Yamada, Kotomi,Hiyama, Tamejiro
, p. 6124 - 6127 (2012/05/07)
Alkynyl aryl ethers react with internal alkynes through selective ortho C-H activation by a palladium(0) catalyst to give substituted 2-methylidene-2H- chromenes. The alkynoxy group acts as a directing group to promote ortho C-H functionalization. Deuterium-labeling experiments indicated that the arylpalladium hydride complex is a key intermediate via oxidative addition. Various functional groups tolerate the present transformation to give the corresponding products.
