137267-48-2Relevant academic research and scientific papers
BENZPYRAZOL DERIVATIVES AS INHIBITORS OF PI3 KINASES
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, (2009/12/28)
The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I) and salts thereof. The compounds of the invention are inhibitors of PI3-kinase activity.
Regioselectivity in the Lithiation of Methyl-substituted Thiazole- and Oxazole-Carboxylic Acids and Carboxamides: General Methods for the Elaboration of Trisubstituted Thiazoles and Oxazoles
Cornwall, Philip,Dell, Colin P.,Knight, David W.
, p. 2417 - 2428 (2007/10/02)
A number of anionic intermediates have been developed which are suitable for the elaboration of trisubstituted thiazoles and oxazoles.Thus, deprotonation of 2,4-dimethylthiazole-5-carboxylic acid 9 using either BuLi or LDA occurs regiospecifically at the
