137269-68-2Relevant academic research and scientific papers
Triazolyl thioamide derivates
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, (2008/06/13)
The invention relates to novel triazolyl thioamides of the general formula (I), STR1 wherein Q represents hydrogen or a heterocyclic group optionally bearing one or more C1-4 alkyl substituent(s), or a group of the formula SR1, wherein R1 stands for straight or branched chained alkyl group comprising 1 to 6 carbon atom(s), or a group of the formula NR2 R3, wherein R2 and R3 each represent hydrogen, straight or branched chained C1-4 alkyl or C2-6 alkenyl group, Y denotes C1-4 alkyl optionally bearing one or more hydroxyl or C1-4 alkoxy substituent(s), phenyl-(C1-4 alkyl) optionally bearing on the phenyl ring one or more C1-4 alkoxy group(s), or phenoxy-(C1-4 alkyl) optionally substituted on the phenyl ring by a C1-4 alkyl bearing a heterocyclic group containing a nitrogen atom, and pharmaceutically acceptable acid addition salts thereof. Furthermore the invention relates to a process for preparing these compounds. The compounds according to the invention possess tranquillant, antidepressant, spacmolytic, antiinflammatory, analgesic and antiperistaltic effects.
On Triazoles. XXV. The Reaction of Methyl (5-Amino-3-Q-1H-1,2,4-triazolyl)dithiocarbonates with Amines
Barkoczy, Jozsef,Reiter, Jozsef
, p. 1597 - 1606 (2007/10/02)
Different "functionalised" triazolylthioamides 3 and -thioureas 4 were synthesised.The ring closure of the ω-hydroxyalkylthioamides 3/2-5 led to the corresponding 2-thiazoline 5/2-4 and 5,6-dihydro-4H-1,3-thiazine 5/5 derivatives, respectively.Unexpectedly, the ring closure of the corresponding 2,2-dimethoxyethyl derivative 3/18 led depending on the reaction conditions to a thiazole derivative 6 or to its 1,2,4-triazolo-1,3,5-triazepin-5(9H)-thione isomer 7 representing a novel ring system.To corroborate its structure 7 was methylated to the corresponding S-methyl derivative 8.Spectroscopical evidence is given for the structure of derivatives 3-8 obtained.
