1372702-74-3

Upstream product

• 1255860-62-8 2-chloro-5,6,7-trimethoxy-4H-chromen-4-one 
• 768-35-4 3-fluorophenylboronic acid 
• 456-48-4 3-Fluorobenzaldehyde 
• 22248-14-2 6-hydroxy-2,3,4-trimethoxyacetophenone 
• 1372702-69-6 C₁₈H₁₇FO₅ 

Downstream Products

• 1342207-69-5 C₁₆H₁₁FO₅ 

Relevant academic research and scientific papers

Scutellarein derivative and preparing method, preparation and application thereof

The invention discloses a scutellarein derivative and a preparing method, a preparation and an application thereof, wherein the scutellarein derivative has the following structure described in the specification, wherein R is a compound residue having biological activity. The preparation method has the advantages of simple and easy implementation, good reproducibility and low environmental pollution, and can be used for large-scale preparation of the scutellarein derivative. The scutellarein derivative is a compound with a brand new structure, has obvious anticoagulant effect, can be used as a potential lead compound, and is applied in preparation of drugs for treatment of deep venous thromboembolism and pulmonary thromboembolism, cardiovascular and cerebrovascular diseases, stroke and other diseases associated with blood coagulation.

Oroxylin A analogs exhibited strong inhibitory activities against iNOS-mediated nitric oxide (NO) production

A number of oroxylin A analogs were prepared and evaluated for their inhibitory activities against iNOS-mediated nitric oxide (NO) production from LPS-stimulated BV2 cells. The analogs were synthesized from purchased 2′-hydroxy-4,5,6-trimethoxyacetophenone and aldehydes in 3 steps. Among the tested compounds, several analogs (3b, 3c, 3d, 3f) exhibited strong inhibitory activities. Especially, the analog with 4-nitrophenyl group (3b) showed stronger inhibitory activity (IC50 = 4.73 μM) than that of wogonin (IC50 = 7.80 μM).