137277-89-5

Upstream product

• 1000996-69-9 6-imino-4-methyl-N,1-diphenyl-1,6-dihydropyridazine-3-carboxamide 
• 135587-62-1 4-methyl-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylic acid ethyl ester 
• 62-53-3 aniline 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 4071-88-9 trimethylsilanyl-acetic acid ethyl ester 
• 3805-62-7 2-(phenylhydrazono)acetoacetanilide 

Relevant academic research and scientific papers

Microwaves in organic synthesis: Facile synthesis of biologically active pyridazinone and iminopyridazine derivatives

(Chemical Equation Presented) Condensation of Wittig reagents 1a,b with arylhydrazones 2a,b by conventional and by microwave heating techniques furnished the corresponding pyridazines 3a-e. The arylhydrazones 7a,b were allowed to react with 1a,b under the same conditions to produce the pyridazinones 10a,b and iminopyridazines 11a,b respectively. On the other hand, the arylhydrazones 12a-c reacted with 1a to afford the pyridazinones 13a-c. Treatment of 3b with dimethylformamide dimethyl acetal (DMFDMA) produced the adduct 15. The utility of microwave heating technique led to the reduction of the reaction times to few minutes and to the improvement of the yields of the products. The in vitro biological activity of some newly prepared compounds against four types of fungi was studied.

A new and convenient synthesis of 3(2H)-pyridazinones by reacting carbanion of ethyl trimethylsilylacetate with phenylhydrazones

A one-pot synthesis of 5,6-disubstituted-2-phenyl-3(2H)-pyridazinones 4 is achieved on treatment of carbanion of ethyl trimethylsilylacetate with phenylhydrazones of 1,2-dicarbonyl compounds 1.