137278-67-2

Upstream product

• 51859-98-4 (2-fluorobenzyl)hydrazine 
• 123-06-8 Ethoxymethylenemalononitrile 
• 446-48-0 o-fluorobenzyl bromide 

Downstream Products

• 137278-91-2 4-Amino-1-(2-fluorobenzyl)-5,6,7,8-tetrahydropyrazolo<3,4-b>quinolin-5-ol 
• 137278-86-5 4-Amino-1-(2-fluorobenzyl)-7,8-dihydro-6H-pyrazolo<3,4-b>quinolin-5-one 
• 154909-73-6 5-amino-1-(2-fluorobenzyl)-4-<3-(2-furyl)-1H-1,2,4-triazol-5-yl>-pyrazole 
• 154909-71-4 5-amino-1-(2-fluorobenzyl)-4-(3-phenyl-1H-1,2,4-triazol-5-yl)-pyrazole 
• 173409-71-7 7-(2-fluorobenzyl)-3,7-dihydro-4H-pyrazolo<3,4-d>-1,2,3-triazin-4-one 
• 173409-70-6 5-amino-1-(2-fluorobenzyl)pyrazole-4-carboxamide 
• 137278-72-9 4-Cyano-1-(2-fluorobenzyl)-5-<(3-oxo-1-cyclohexen-1-yl)amino>pyrazole 

Relevant academic research and scientific papers

Synthesis and anticonvulsant activity of N-benzylpyrrolo[2,3-d]-, - pyrazolo[3,4-d]-, and -triazolo[4,5-d]pyrimidines: Imidazole ring-modified analogues of 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine

Analogues of 9-(2-fluorobenzyl)-6-(methylamino)-9H-purine (1) containing isosteric replacements of the imidazole ring atoms were synthesized and tested for anticonvulsant activity. The pyrrolo[2,3-d]-, pyrazolo[a,4-d]-, and triazolo[4,5-d]pyrimidines were less active than 1 against maximal electroshock-induced seizures (MES) in rats when given po. The differences in anti-MES activity for these analogues was not explained by differences in pK(a) or lipophilicity. However, the four classes of heterocycles have distinctly different calculated electrostatic isopotential maps, which may be related to optimum anticonvulsant activity.

Synthesis of 7,8-Dihydro-6H-pyrazoloquinolin-5-ones and Related Derivatives

This paper describes the synthesis of a new series of 4-amino-1-(unsubstituted and chloro or fluoro substituted benzyl)-7,8-dihydro-6H-pyrazoloquinolin-5-ones 8 and the corresponding 7,8-dihydro-6H,9H-pyrazoloquinoline-4,5-diones 13.The deri