1372796-92-3

Basic information

• Product Name: 1-(docosyloxy)-3-(trityloxy)propan-2-ol
• Synonyms: 1-(docosyloxy)-3-(trityloxy)propan-2-ol
• CAS NO: 1372796-92-3
• Molecular Weight: 643.006
• Mol File: 1372796-92-3.mol

Chemical Properties

• CAS DataBase Reference: 1-(docosyloxy)-3-(trityloxy)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(docosyloxy)-3-(trityloxy)propan-2-ol(1372796-92-3)
• EPA Substance Registry System: 1-(docosyloxy)-3-(trityloxy)propan-2-ol(1372796-92-3)

Safety Data

• Hazardous Substances Data: 1372796-92-3(Hazardous Substances Data)

Upstream product

• 123253-22-5 docosyl mesylate 
• 145403-22-1 3-(n-docosyloxy)propane-1,2-diol 
• 76-83-5 trityl chloride 
• 171364-93-5 4-(n-docosyloxymethyl)-2,2-dimethyl-1,3-dioxolane 

Downstream Products

• 1372796-93-4 1-docosyl-2-isostearoyl-3-trityl glycerol 

Relevant articles and documents

Design, synthesis and cytotoxicity of chimeric erlotinib-alkylphospholipid hybrids

Two series of erlotinib-alkylphospholipid hybrids were prepared and evaluated for their antiproliferative activities against a panel of four cell lines representing lung, breast, liver and skin cancers using erlotinib and miltefosine as reference standards. Amide analogs elicited more enhanced cytotoxic activity than analogous esters. Amide derivatives 8d and 8e exhibited promising broad-spectrum antiproliferative activity and higher efficacy than reference erlotinib and miltefosine. Their cellular GI50 values was in the ranges of 24.7–46.9 μM and 26.8–43.1 μM for 8e and 8d respectively. Assay results of the inhibitory activity of the prepared compounds on EGFR kinase reaction and Akt phosphorylation in conjugation with statistical correlation analysis indicated that other mechanisms might contribute to their elicited cytotoxicities. In addition, statistical correlation analysis revealed that mechanisms of elicited cytotoxicities for amide series might be different from ester series. In addition, correlation analysis indicated variations in the mechanisms according to the types of cell line.

Asymmetric 1-alkyl-2-acyl phosphatidylcholine: A helper lipid for enhanced non-viral gene delivery

Rationally designed asymmetrical alkylacyl phosphatidylcholines (APC) have been synthesized and evaluated as helper lipids for non-viral gene delivery. A long aliphatic chain (C22-C24) was introduced at the 1-position of glycerol backbone, a branched lipid chain (C18) at the 2-position, and a phosphocholine head group at the 3-position. The fusogenicity of APC depends on the length and degree of saturation of the alkyl chain. Cationic lipids were formulated with APC as either lipoplexes or nanolipoparticles, and evaluated for their stability, transfection efficiency, and cytotoxicity. APC mediated high in vitro transfection efficiency, and had low cytotoxicity. Small nanolipoparticles (less than 100 nm) can be obtained with APC by applying as low as 0.1% PEG-lipid. Our study extends the type of helper lipids that are suitable for gene transfer and points the way to improve non-viral nucleic acid delivery system other than the traditional cationic lipids optimization.