1372797-30-2

Upstream product

• 93246-53-8 3-fluoro-4-(morpholinyl)aniline 
• 2689-39-6 3-fluoro-4-(4-morpholinyl)nitrobenzene 
• 369-34-6 3,4-difluoronitrobenzene 
• 1372797-29-9 2-{[3-fluoro-4-(morpholin-4-yl)phenyl]amino}acetohydrazide 
• 1544-68-9 4-fluorophenyl isothiocyanate 

Downstream Products

• 1372797-31-3 4-(4-fluorophenyl)-5-({[3-fluoro-4-(morpholin-4-yl)phenyl]amino}methyl)-4H-1,2,4-triazole-3-thiol 
• 1372797-32-4 5-({[3-fluoro-4-(morpholin-4-yl)phenyl]amino}methyl)-N-(4-fluorophenyl)-1,3,4-thiadiazol-2-amine 
• 1372797-33-5 N'-[(2Z)-3-(4-fluorophenyl)-4-oxo-1,3-thiazolidin-2-ylidene]-2-{[3-fluoro-4-(morpholin-4-yl)phenyl]amino}acetohydrazide 
• 1372797-34-6 N'-[(2Z)-5-(4-chlorophenyl)-3-(4-fluorophenyl)-1,3-thiazol-2(3H)-ylidene]-2-{[3-fluoro-4-(morpholin-4-yl)phenyl]amino}acetohydrazide 

Relevant academic research and scientific papers

Synthesis of linezolid-like molecules and evaluation of their antimicrobial activities

3-Fluoro-4-(morpholin-4-yl)aniline (2), prepared from 3,4- difluoronitrobenzene, was converted to the corresponding Schiff base (3) by treatment with indol-3-carbaldehyde. The treatment of thiourea 4 and carbothioamide derivatives 9 with ethyl bromoacetate or 4-substituted phenacyl bromides generated the corresponding thiazolidinone (5 and 13) and thiazoline (6 and 12) derivatives, respectively. The acidic or basic treatment of carbothioamide 9 produced 1,3,4-thiadiazole (11) or 1,2,4-triazole (10) compounds, respectively. The structural assignments of the new compounds were based on elemental analysis and spectral (IR, 1H-NMR, 13C-NMR, and LC-MS) data. The antimicrobial activity study revealed that all compounds showed good antitubercular activities. TUeBITAK.