13728-11-5

Usage

Uses

Used in Pharmaceutical Industry:
[(4-chlorophenyl)(nitroso)amino]acetic acid is used as an organic synthesis intermediate for the production of pharmaceuticals. Its unique structure and functional groups make it a valuable component in the development of new drugs.
Used in Research and Development:
In the field of research and development, [(4-chlorophenyl)(nitroso)amino]acetic acid is utilized for studying its potential anti-inflammatory and anti-cancer properties. These studies aim to explore its therapeutic potential and contribute to the advancement of medical treatments.
Used in Environmental Monitoring:
As a known metabolic product of certain pesticides and a potential environmental pollutant, [(4-chlorophenyl)(nitroso)amino]acetic acid is used in environmental monitoring and assessment. Its detection and analysis help in understanding the impact of pesticide use on the environment and human health.

Upstream product

• 2521-89-3 ethyl 2-((4-chlorophenyl)amino)acetate 
• 106-47-8 4-chloro-aniline 
• 5465-90-7 N-(4-chlorophenyl)glycine 

Downstream Products

• 829-31-2 3-(4-chlorophenyl)sydnone 
• 86388-64-9 3,4-bis(4-chlorophenyl)sydnone 
• 1225057-50-0 2-(4-chlorophenyl)-3-phenylethynyl-2H-indazole 
• 1225057-49-7 2-(4-chlorophenyl)-3-(2-pyridyl)-2H-indazole 
• 1225057-48-6 2-(4-chlorophenyl)-3-(2-thiophenyl)-2H-indazole 
• 1225057-59-9 3-(4-chlorophenyl)-4-(phenylethynyl)sydnone 
• 1225057-58-8 3-(4-chlorophenyl)-4-(2-pyridyl)sydnone 
• 1225057-57-7 3-(4-chlorophenyl)-4-(2-thiophenyl)sydnone 
• 1225057-55-5 3-(4-chlorophenyl)-4-(4-methoxyphenyl)sydnone 
• 131458-85-0 2-[1-(4-Chloro-phenyl)-1H-pyrazol-4-ylmethoxy]-2-methyl-propionic acid methyl ester 
• 131458-83-8 2-[1-(4-Chloro-phenyl)-1H-pyrazol-3-ylmethoxy]-2-methyl-propionic acid methyl ester 
• 131458-84-9 2-[1-(4-Chloro-phenyl)-1H-pyrazol-4-ylmethoxy]-2-methyl-propionic acid 
• 131458-82-7 2-[1-(4-Chloro-phenyl)-1H-pyrazol-3-ylmethoxy]-2-methyl-propionic acid 

Relevant academic research and scientific papers

Novel sydnone derivatives carrying azidomethyl-1,2, 4-oxadiazole unit and their 1,3-dipolar cycloadditions

A series of 1,2,4-oxadiazolymethyl sydnones carrying azido group were synthesized and subjected to react with a variety of alkenic and acetylenic dipolarophilic reagents; N-phenyl maleimide, phenyl vinyl sulfone, and phenyl propiolic acid. All the new products are identified by spectral/physical data including high-resolution mass measurements and X-ray diffraction data.

Synthesis of 2 H-indazoles by the [3 + 2] dipolar cycloaddition of sydnones with arynes

A rapid and efficient synthesis of 2H-indazoles has been developed using a [3 + 2] dipolar cycloaddition of sydnones and arynes. A series of 2H-indazoles have been prepared in good to excellent yields using this protocol, and subsequent Pd-catalyzed coupl

Synthesis of 2H-indazoles by the [3 + 2] cycloaddition of arynes and sydnones

A rapid and efficient synthesis of 2H-indazoles has been developed, which involves the [3 + 2] dipolar cycloaddition of arynes and sydnones. The process proceeds under mild reaction conditions in good to excellent yields.

Synthesis and evaluation of phenyl substituted sydnones as potential DPPH-radical scavengers

A series of phenyl substituted sydnones has been synthesized and their radical-scavenging activity has been studied on DPPH free radical. Out of eighteen compounds screened, nine compounds show interesting activity. A mechanism is presented whereby sydnones scavenge DPPH radical through donating H-atom at 4th-position. Its strong radical-scavenging activity mainly arises from 1, 2, 3-oxadiazolium-5-olate ring. Different substituents and their positions on the phenyl ring differently influence DPPH scavenging activity and therefore, may provide clues to design and develop better free-radical scavenging sydnones with multiple activities.

Microwave-assisted synthesis of N-arylglycines: Improvement of sydnone synthesis

Reactions of anilines with ethyl bromoacetate under microwave irradiation have afforded N-arylglycines that are subsequently converted to their N-nitroso derivatives with a combination of silica chloride or periodic acid, wet SiO2 and sodium nitrite in CH2Cl2 with satisfactory yields. In the final step, the use of 1,3-dibromo-5,5-dimethylhydantoin (DBH) as a new and effective reagent for dehydration of N-nitroso-N-arylglycines to sydnones was successfully examined.