1372807-55-0

Basic information

• Product Name: 1-(2-p-tolyl-ethyl)-5,6,7,8-tetrahydroisoquinoline
• Synonyms: 1-(2-p-tolyl-ethyl)-5,6,7,8-tetrahydroisoquinoline
• CAS NO: 1372807-55-0
• Molecular Weight: 251.371
• Mol File: 1372807-55-0.mol

Chemical Properties

• CAS DataBase Reference: 1-(2-p-tolyl-ethyl)-5,6,7,8-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-p-tolyl-ethyl)-5,6,7,8-tetrahydroisoquinoline(1372807-55-0)
• EPA Substance Registry System: 1-(2-p-tolyl-ethyl)-5,6,7,8-tetrahydroisoquinoline(1372807-55-0)

Safety Data

• Hazardous Substances Data: 1372807-55-0(Hazardous Substances Data)

Upstream product

• 932-66-1 1-cyclohexenyl methyl ketone 
• 117369-95-6 1-Acetyl-2-ethenylcyclohexane 

Relevant articles and documents

Investigation on amino-heck cyclization of 1-(2-vinylcyclohexyl)ketone diethyl phosphinyloximes

Upon the treatment with Pd(PPh3)4 and Et3N in DMF at 80 °C, a range of trans-1-(2-vinylcyclohexyl)-substituted ketone diethylphosphinyloximes underwent the cyclization in a 6-endo pathway to afford 1-substituted tetrahydroisoquinolines in varying yields. Among which, the reactions of the substrates bearing the saturated alkyl groups were severely competed by hydrolysis and/or Beckmann rearrangement, while these undesired side reactions could be suppressed by introducing a β-aryl moiety possibly due to the stabilizing π-π stacking interactions between the phosphoryl and/or vinyl group and the aryl.