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(2R,5S)-4-(3-chloro-4-cyanophenyl)-N-(2-methoxypyrimidin-5-yl)-2,5-dimethylpiperazine-1-carboxamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1372927-80-4

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1372927-80-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1372927-80-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,2,9,2 and 7 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1372927-80:
(9*1)+(8*3)+(7*7)+(6*2)+(5*9)+(4*2)+(3*7)+(2*8)+(1*0)=184
184 % 10 = 4
So 1372927-80-4 is a valid CAS Registry Number.

1372927-80-4Downstream Products

1372927-80-4Relevant academic research and scientific papers

ANTAGONIST FOR MUTANT ANDROGEN RECEPTOR

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Paragraph 0152, (2013/08/14)

[Problem] An object of the present invention is to provide a novel anticancer drug which is useful for treating prostate cancer accompanying androgen receptor mutation [Means for Solution] The present inventors conducted thorough research on mutant androgen-related diseases for which the traditional anti-androgen drugs become ineffective. As a result, they found that the compound, which is an active ingredient of the pharmaceutical composition of the present invention, exhibits an inhibitory action against transcriptional activation in a human mutant androgen receptor (AR), and has an excellent antitumor action in a human prostate cancer-bearing mouse, thereby completing the present invention. Accordingly, the compound, which is an active ingredient of the pharmaceutical composition of the present invention, is useful for a series of androgen receptor-related diseases including prostate cancer.

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