137295-72-8Relevant academic research and scientific papers
Inhibition of papain by peptide nitriles: conversion of the nitrile group into other functionalities via the papain:nitrile thioimidate ester adduct
Gour-Salin, Barbara J.,Lachance, Paule,Storer, Andrew C.
, p. 1288 - 1297 (2007/10/02)
Peptide nitriles are reversible inhibitors of papain that form thioimidates with the cysteine thiol in the enzyme's active site.These thioimidates undergo reactions with thiols and amines to form acids and amidines, respectively.These reactions were also
