137296-52-7

Upstream product

• 41078-02-8 3-propylxanthine 
• 824-94-2 p-methoxybenzyl chloride 
• 76194-09-7 6-amino-5-formamido-1-n-propyl-2,4-(1H,3H)-pyrimidinedione 

Downstream Products

• 137296-35-6 1-But-3-enyl-7-(4-methoxy-benzyl)-3-propyl-3,7-dihydro-purine-2,6-dione 
• 1027597-28-9 1-Butyl-7-(4-methoxy-benzyl)-3-propyl-3,7-dihydro-purine-2,6-dione 
• 1026686-34-9 1-(2-Ethoxy-ethyl)-7-(4-methoxy-benzyl)-3-propyl-3,7-dihydro-purine-2,6-dione 
• 137296-31-2 1-(3-Dimethylamino-propyl)-7-(4-methoxy-benzyl)-3-propyl-3,7-dihydro-purine-2,6-dione 
• 137296-25-4 3-[7-(4-Methoxy-benzyl)-2,6-dioxo-3-propyl-2,3,6,7-tetrahydro-purin-1-yl]-propionitrile 
• 1025953-50-7 1-Ethyl-7-(4-methoxy-benzyl)-3-propyl-3,7-dihydro-purine-2,6-dione 
• 1027901-68-3 7-(4-Methoxy-benzyl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione 
• 137296-29-8 1-(3-Hydroxy-propyl)-7-(4-methoxy-benzyl)-3-propyl-3,7-dihydro-purine-2,6-dione 
• 31542-62-8 1,3-dipropylxanthine 
• 896420-11-4 1-(4-chlorobenzyl)-3-propyl-3,7-dihydro-1H-purine-2,6-dione 
• 137296-24-3 [7-(4-Methoxy-benzyl)-2,6-dioxo-3-propyl-2,3,6,7-tetrahydro-purin-1-yl]-acetonitrile 
• 137296-28-7 1-(2-Hydroxy-ethyl)-7-(4-methoxy-benzyl)-3-propyl-3,7-dihydro-purine-2,6-dione 
• 137296-32-3 7-(4-Methoxy-benzyl)-1-(2-methoxy-ethyl)-3-propyl-3,7-dihydro-purine-2,6-dione 
• 137296-26-5 7-(4-Methoxy-benzyl)-1-(2-oxo-propyl)-3-propyl-3,7-dihydro-purine-2,6-dione 

Relevant academic research and scientific papers

Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position

Xanthine derivatives with several functional groups at the 1- or 7- position were synthesized, and their pharmacological activities in guinea pigs were studied. In general, the in vitro tracheal relaxant action and positive chronotropic action of 3-propyl

Effects of Alkyl Substitutions of Xanthine Skeleton on Bronchodilation

Structure-activity relationships in a series of 1,3,7-trialkyl-xanthine were studied with guinea pigs.Relaxant actions in the tracheal muscle were increased with alkyl chain length at the 1- and 3-positions of the xanthine skeleton, but decreased by alkylation at the 7-position.Positive chronotropic actions in the right atrium were potentiated with 3-alkyl chain length but tended to decrease with 1-alkylation and diminish by 7-substitution.Consequently, while the 1- and 3-substitutions were equally important for the tracheal smooth muscle relaxation, the substitution at the 1-position was more important than the 3-substitution for bronchoselectivity.The 7-alkylation may be significant to cancel heart stimulation.There were good correlations between the smooth muscle relexant action and the cyclic AMP-PDE inhibitory activity in 3-substituents and the affinity for adenosine (A1)receptors in 1-,3-, and 7-substituents.This suggests that not only the cyclic AMP-PDE inhibitory activity but also the adenosine antagonistic activity is important in the bronchodilatory effects of alkylxanthines.Among these xanthine derivatives, 1-butyl-3-propylxanthine and its 7-methylated derivative showed high bronchoselectivity in the in vitro and in vivo experiments compared to theophylline and enprofylline and may be new candidates for bronchodilator.