1372996-86-5Relevant academic research and scientific papers
Catalytic Generation of C1 Ammonium Enolates from Halides and CO for Asymmetric Cascade Reactions
Li, Lu-Lu,Ding, Du,Song, Jin,Han, Zhi-Yong,Gong, Liu-Zhu
supporting information, p. 7647 - 7651 (2019/05/15)
A general strategy for the design of asymmetric cascade reactions using readily available halides and carbon monoxide (CO) as substrates is developed. The key is the catalytic generation of C1-ammonium enolates for the subsequent asymmetric cascade reactions through the combination of palladium-catalyzed carbonylation and chiral Lewis base catalysis. Utilizing this strategy, we have established asymmetric formal [1+1+4] and [1+1+2] reactions to afford chiral dihydropyridones and β-lactams with high yields and high enantio- and diastereoselectivities.
An Upstream By-product from Ester Activation via NHC-Catalysis Catalyzes Downstream Sulfonyl Migration Reaction
Han, Runfeng,He, Liwenze,Liu, Lin,Xie, Xingang,She, Xuegong
supporting information, p. 193 - 197 (2016/03/01)
A sequential reaction combining N-heterocyclic carbene (NHC) and N-hydroxyphthalimide (NHPI) catalysis allowed for the upstream by-product NHPI, which was generated in the NHC-catalyzed cycloaddition reaction, to act as the catalyst for a downstream nitro
Enantioselective activation of stable carboxylate esters as enolate equivalents via N-heterocyclic carbene catalysts
Hao, Lin,Du, Yu,Lv, Hui,Chen, Xingkuan,Jiang, Huishen,Shao, Yaling,Chi, Yonggui Robin
, p. 2154 - 2157 (2012/07/14)
The first N-Heterocyclic Carbene (NHC) mediated activation of stable carboxylate esters to generate enolate intermediates is disclosed. The catalytically generated arylacetic ester enolates undergo enantioselective reactions with α,β-unsaturated imines.
