1373015-72-5

Basic information

• Product Name: C₁₄H₂₆BO₂P
• Synonyms: C₁₄H₂₆BO₂P
• CAS NO: 1373015-72-5
• Molecular Weight: 268.144
• Mol File: 1373015-72-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₄H₂₆BO₂P(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₂₆BO₂P(1373015-72-5)
• EPA Substance Registry System: C₁₄H₂₆BO₂P(1373015-72-5)

Safety Data

• Hazardous Substances Data: 1373015-72-5(Hazardous Substances Data)

Upstream product

• 203000-43-5 tert-butyldimethylphosphine borane complex 
• 874-98-6 1-bromomethyl-3-methoxybenzene 
• 281667-49-0 (R)-tert-butyl(hydroxymethyl)methylphosphine borane 

Relevant articles and documents

Parallel and modular synthesis of P-chirogenic P,O-ligands

A modular synthesis of P-chirogenic α-alkoxyphosphine ligands has been developed, allowing for the variation of two of the three groups on phosphorus. Oxidation and concomitant desymmetrization of a prochiral alkyl- or aryldimethylphosphine borane afforded α-hydroxyphosphines, which were subsequently deprotonated and alkylated in a parallel fashion. The choice of base and temperature for the alkylation step was found to be crucial for the outcome of the reaction. Selected ligands were subsequently screened in palladium catalyzed allylic substitution, affording product in good to excellent yield but moderate enantioselectivity, indicating that further optimization of the ligand structures is desirable to increase the stereoselectivity.