137302-86-4

Upstream product

• 124278-39-3 N-(4-MorpholinYlsulfonyl)-L-phenylalanine 
• 134334-91-1 (1S,2R)-<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholino)ethyl>amino>-2-hydroxy-4-oxobutyl>amine 
• 137429-58-4 1,1-dimethylethyl <1(S)-(cyclohexylmethyl)-3,3-difluoro-2(R)-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>carbamate 
• 118233-28-6 (3R,4S)-4-tert-Butoxycarbonylamino-5-cyclohexyl-2,2-difluoro-3-hydroxy-pentanoic acid 
• 103322-58-3 ethyl 4(S)-<(tert-butyloxycarbonyl)amino>-5-(cyclohexylmethyl)-2,2-difluoro-3(R)-hydroxypentanoate 
• 98105-42-1 (S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal 
• 2038-03-1 4-(2-AMINOETHYL)MORPHOLINE 

Downstream Products

• 135760-09-7 (S)-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-<1-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholinyl)ethyl>amino>-2,4-dioxobutyl>-L-alaninamide 
• 137302-87-5 (4-{(S)-2-[(S)-1-Cyclohexylmethyl-3,3-difluoro-3-(2-morpholin-4-yl-ethylcarbamoyl)-2-oxo-propylcarbamoyl]-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-ethyl}-thiazol-2-yl)-carbamic acid trichloromethyl ester 
• 137429-59-5 -N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-<1-(cyclohexylmethyl)-3,3-difluoro-2-hydroxy-4-<<2-(4-morpholinyl)ethyl>amino>-4-oxobutyl>-L-alaninamide 

Relevant academic research and scientific papers

Design and Synthesis of Potent, Selective, and Orally Active Fluorine-Containing Renin Inhibitors

A series of primate renin inhibitors containing difluorocarbinol and difluoroketone groups at the P1 - P1' position have been synthesized and studied both in vitro and in vivo.In vitro, the compounds were evaluated as inhibitors of m