1373121-49-3Relevant academic research and scientific papers
Copper-catalyzed enantioselective inverse electron-demand hetero-diels-alder reactions of diazadienes with enol ethers: Efficient synthesis of chiral pyridazines
Gao, Shuang,Chen, Jia-Rong,Hu, Xiao-Qiang,Cheng, Hong-Gang,Lu, Liang-Qiu,Xiao, Wen-Jing
, p. 3539 - 3544 (2013)
A highly efficient and enantioselective inverse electron-demand hetero-Diels-Alder reaction of in situ generated 1,2-diaza-1,3-dienes with enol ethers has been developed with the use of a chiral copper/bisoxazoline complex as the catalyst. The reaction ex
Enantioselective synthesis of dihydropyrazoles by formal [4+1] cycloaddition of in situ-derived azoalkenes and sulfur ylides
Chen, Jia-Rong,Dong, Wan-Rong,Candy, Mathieu,Pan, Fang-Fang,Joerres, Manuel,Bolm, Carsten
supporting information; experimental part, p. 6924 - 6927 (2012/06/15)
An unprecedented strategy to access highly enantioenriched dihydropyrazoles is described. It involves formal [4+1] cycloadditions of in situ-derived azoalkenes and sulfur ylides catalyzed by a chiral copper/Tol-BINAP complex. A variety of synthetically and biologically important dihydropyrazoles have been obtained with high enantioselectivities (up to 97:3 er) in good yields (83-97%).
