1373133-12-0

Basic information

• Product Name: (R)-ethyl 2-hydroxy-4-(o-tolyl)-2-(trifluoromethyl)pent-4-enoate
• Synonyms: (R)-ethyl 2-hydroxy-4-(o-tolyl)-2-(trifluoromethyl)pent-4-enoate
• CAS NO: 1373133-12-0
• Molecular Weight: 302.293
• Mol File: 1373133-12-0.mol

Chemical Properties

• CAS DataBase Reference: (R)-ethyl 2-hydroxy-4-(o-tolyl)-2-(trifluoromethyl)pent-4-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-ethyl 2-hydroxy-4-(o-tolyl)-2-(trifluoromethyl)pent-4-enoate(1373133-12-0)
• EPA Substance Registry System: (R)-ethyl 2-hydroxy-4-(o-tolyl)-2-(trifluoromethyl)pent-4-enoate(1373133-12-0)

Safety Data

• Hazardous Substances Data: 1373133-12-0(Hazardous Substances Data)

Upstream product

• 7399-49-7 1-methyl-2-(prop-1-en-2-yl)benzene 
• 13081-18-0 ethyl-3,3,3-trifluoropyruvate 
• 577-16-2 2-Methylacetophenone 

Relevant articles and documents

Asymmetric carbonyl-ene reaction of trifluoropyruvate catalyzed by Pd(II)-SunPhos complex

An efficient asymmetric carbonyl-ene reaction of trifluoropyruvate catalyzed by chiral Pd(II)/(S)-SunPhos complex was developed. A series of optically active homoallylic alcohols containing a CF3 group were obtained with high yields and excellent ee under mild conditions. Particularly, the reaction of isobutylene and trifluoropyruvate gave the desired product (90% yield, 98% ee) with catalyst loading as low as 0.01 mol% in dichloroethane/toluene.

Asymmetric carbonyl-ene and Friedel-Crafts reactions catalysed by Lewis acid platinum group metal complexes of the enantiopure atropisomeric biaryl-like diphosphine (S)-Me2-CATPHOS: A comparison with BINAP

Lewis acid platinum and palladium complexes of (S)-Me2-CATPHOS catalyse the carbonyl-ene reaction between allylbenzene derivatives and ethyl trifluoropyruvate to give the expected α-hydroxy esters with ee's up to 97%, while the corresponding re