1373162-63-0Relevant academic research and scientific papers
Design and synthesis of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2- yl)-1H-quinolin-2-ones as VEGFR-2 kinase inhibitors
Han, Sun-Young,Choi, Jie Won,Yang, Jeon,Chae, Chong Hack,Lee, Jongkook,Jung, Heejung,Lee, Kwangho,Ha, Jae Du,Kim, Hyoung Rae,Cho, Sung Yun
scheme or table, p. 2837 - 2842 (2012/05/20)
A series of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H- quinolin-2-ones have been identified as a new class of VEGFR-2 kinase inhibitors. A variety of (4,5,6,7-tetrahydro-imidazo[5,4-c]pyridin-2-yl)-acetic acid ethyl esters were synthesized, and their VEGFR-2 inhibitory activity was evaluated. Described herein are the preparation of the series and the effects of the compounds on VEGFR-2 kinase activity.
