1373162-75-4Relevant academic research and scientific papers
Synthesis and biological evaluation of novel small non-peptidic HIV-1 PIs: The benzothiophene ring as an effective moiety
Chiummiento, Lucia,Funicello, Maria,Lupattelli, Paolo,Tramutola, Francesco,Berti, Federico,Marino-Merlo, Francesca
, p. 2948 - 2950 (2012)
Synthesis and biological evaluation of a new series of potential HIV-1 protease inhibitors incorporating different heterocycles are described. The variation of heteroatom in such molecules has displayed totally different biological activities and a benzothiophene containing inhibitor has shown high potency against wild type HIV-1 protease with IC50 = 60 nM, thanks to the lower desolvation penalty to be payed by such hydrophobic moiety.
