1373165-95-7Relevant academic research and scientific papers
Air-stable and highly efficient indenyl-derived phosphine ligand: Application to Buchwald-Hartwig amination reactions
Hao, Xiaowei,Yuan, Jia,Yu, Guang-Ao,Qiu, Ming-Qiang,She, Neng-Fang,Sun, Yue,Zhao, Cui,Mao, Shu-Lan,Yin, Jun,Liu, Sheng-Hua
, p. 99 - 105 (2012)
2-Mesitylindenyl phosphine ligand (1) and [(2-mesitylindenyl)dicyclohexyl- phosphine]PdCl2 (2) have been synthesized and fully characterized by NMR and elemental analysis, as well as by X-ray crystallography for 2. A Highly active catalyst system derived from a palladium precatalyst and bulky 2-mesitylindenyl phosphine ligand (1) for the Buchwald-Hartwig amination reaction of aryl halides with primary and secondary amines has been developed. This method allows for the preparation of a wide variety of amines in moderate to excellent yields and displays a high level of activity for the coupling of aryl chlorides as well as hindered aryl bromides.
