1373277-76-9

Upstream product

• 1373278-67-1 methyl 5-(3-(4-fluorophenyl)-7-((hydroxyimino)methyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate 
• 1373278-66-0 methyl 5-(3-(4-fluorophenyl)-7-formyl-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate 
• 1373278-06-8 methyl 5-(7-bromo-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate 
• 1373278-04-6 4-bromo-2-(6-methoxy-6-oxohexanamido)benzoic acid 
• 35444-44-1 methyl adipoyl chloride 
• 20776-50-5 2-amino-4-bromobenzoic acid 
• 1373278-93-3 methyl 5-(7-(5-(benzo[d]oxazol-2-yl)-5-methyl-4,5-dihydroisoxazol-3-yl)-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)pentanoate 

Relevant academic research and scientific papers

Quality by design (QbD) of amide isosteres: 5,5-Disubstituted isoxazolines as potent CRTh2 antagonists with favorable pharmacokinetic and drug-like properties

Isoxazoles are frequently used amide isosteres, as shown in the context of discovery of CRTh2 antagonists from amide 1 to isoxazole 2. However, persistent agonism and poor solubility in isoxazole series presented challenges to its further devel