137333-69-8Relevant academic research and scientific papers
Enantioselective dialkylation of 1,2-phthalicdicarboxaldehyde
Kleijn, Henk,Jastrzebski, Johann T.B.H.,Boersma, Jaap,Van Koten, Gerard
, p. 3933 - 3937 (2007/10/03)
A new two-step, one-pot procedure is reported for the enantioselective synthesis of C2-symmetric diols derived from 1,2-phthalicdicarboxaldehyde. The first step involves the enantioselective addition of a dialkylzinc compound to one of the aldehyde groups, affording a lactol organozinc derivative. In the second step this lactol derivative is converted to the appropriate diol with the aid of a Grignard reagent and subsequent hydrolysis. This methodology also allows the synthesis of unsymmetric diols.
ENANTIOFACE-DIFFERENTIATING ADDITION OF A CHIRAL ARYLLITHIUM REAGENT TO ALDEHYDES
Asami, Masatoshi,Mukaiyama, Teruaki
, p. 17 - 20 (2007/10/02)
A chiral aryllithium reagent was prepared by treating a chiral aminal, derived from (S)-2-(anilinomethyl)pyrrolidine and o-bromobenzaldehyde, with n-butyl lithium.The chiral reagent reacted highly enantioface selectively with aliphatic aldehydes and, on h
