1373334-63-4Relevant academic research and scientific papers
Cobalt-Catalyzed Cross-Coupling of 3- and 4-Iodopiperidines with Grignard Reagents
Gonnard, Laurine,Gurinot, Amandine,Cossy, Janine
, p. 12797 - 12803 (2015/09/01)
A cobalt-catalyzed cross-coupling between 3- and 4-iodopiperidines and Grignard reagents is disclosed. The reaction is an efficient, cheap, chemoselective, and flexible way to functionalize piperidines. This coupling was used as the key step to realize a short synthesis of (±)-preclamol. Some mechanistic investigations were conducted that highlight the formation of radical intermediates. Scaffold synthesis: A cobalt-catalyzed cross-coupling between iodopiperidines and Grignard reagents is reported (see scheme; PG=protecting group). A large variety of 3- and 4-substituted piperidines were synthesized and the method was applied to a short synthesis of (±)-preclamol. This work constitutes one of the rare examples of cross-couplings involving 3-halogeno piperidines.
Ni-catalyzed reductive allylation of unactivated alkyl halides with allylic carbonates
Dai, Yijing,Wu, Fan,Zang, Zhenhua,You, Hengzhi,Gong, Hegui
supporting information; experimental part, p. 808 - 812 (2012/02/16)
Game of two electrophiles: Two partially positively charged sp3 carbon atoms can be connected by using a catalytic Ni species in the presence of an environmentally benign Zn reductant, delivering allylated alkanes (see scheme). This unprecedent
