1373334-75-8Relevant academic research and scientific papers
Photoredox Polyfluoroarylation of Alkyl Halides via Halogen Atom Transfer
Blackburn, Bryan G.,Cooke, Maria Victoria,Laulhé, Sébastien,Niu, Ben,Sachidanandan, Krishnakumar
, p. 916 - 920 (2022/02/07)
Polyfluoroarene moieties are of interest in medicinal chemistry, agrochemicals, and material sciences. Herein, we present the first polyfluoroarylation of unactivated alkyl halides via a halogen atom transfer process. This method converts primary, secondary, and tertiary alkyl halides into the respective polyfluoroaryl compounds in good yields in the presence of amide, carbamate, ester, aromatic, and sulfonamide moieties, including derivatives of complex bioactive molecules. Mechanistic work revealed that this transformation proceeds through an alkyl radical generated after the halogen atom transfer.
Ni-catalyzed reductive allylation of unactivated alkyl halides with allylic carbonates
Dai, Yijing,Wu, Fan,Zang, Zhenhua,You, Hengzhi,Gong, Hegui
, p. 808 - 812 (2012/02/16)
Game of two electrophiles: Two partially positively charged sp3 carbon atoms can be connected by using a catalytic Ni species in the presence of an environmentally benign Zn reductant, delivering allylated alkanes (see scheme). This unprecedent
