1373347-49-9

Upstream product

• 615-43-0 2-iodophenylamine 
• 109-01-3 1-methyl-piperazine 
• 1233977-64-4 N-(2-iodophenyl)-N'-cyano-S-methylisothiourea 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 1-cyano-2-Amino-benzimidazole derivatives as a novel class of antitumor agents

A series of 1-cyano-2-Amino-benzimidazole derivatives were synthesized and evaluated for their cytotoxic activities in vitro against three human cancer cell lines (human lung carcinoma cell line: A549, human leukemia cell line: K562, and human prostate cancer cell line: PC-3). Most of these compounds showed potent activities against these tumor cell lines, especially against A549 and K562 cell lines. The preliminary structure-Activity relationships of 1-cyano-2-Amino-benzimidazole derivatives were also discussed. The cell cycle analysis was carried out in K562 cells and the results showed that compound 4d caused a marked increase of cells in G 2/M phase.

Copper(I)-catalyzed intramolecular C-N coupling reactions to form 1-cyanobenzimidazoles

Employing a CuI/2,2'-biimidazole catalyst system, the intramolecular C-N coupling reactions of various substituted aryl guanidines could be successfully carried out under mild conditions. A variety of 1-cyanobenzimidazoles were synthesized in good to excellent yields. ARKAT-USA, Inc.