1373353-97-9

Upstream product

• 617-35-6 2-oxo-propionic acid ethyl ester 
• 29601-98-7 N-benzylhydroxylamine hydrochloride 

Downstream Products

• 1373354-07-4 (3R,4S,5R)-ethyl 2-benzyl-4-formyl-3,5-dimethylisoxazolidine-3-carboxylate 
• 1373354-25-6 (3R,4S,5R)-ethyl 2-benzyl-4-formyl-3,5-dimethylisoxazolidine-3-carboxylate 
• 1373354-16-5 (3R,4R,5R)-2-benzyl-3-ethoxycarbonyl-4-hydroxymethyl-3,5-dimethylisoxazolidine 
• 1373354-12-1 (3R,4S,5R)-ethyl 2-benzyl-5-ethyl-4-formyl-3-methylisoxazolidine-3-carboxylate 
• 1373354-22-3 (3R,4R,5R)-ethyl 2-benzyl-5-ethyl-4-(hydroxymethyl)-3-methylisoxazolidine-3-carboxylate 
• 1593585-89-7 (+)-(3R,5S)-ethyl 2-benzyl-5-formyl-3,5-dimethylisoxazolidine-3-carboxylate 

Relevant academic research and scientific papers

The asymmetric organocatalytic 1,3-dipolar cycloaddition of alkyl pyruvate-derived nitrones and α,β-unsaturated aldehydes

The catalytic asymmetric 1,3-dipolar cycloaddition of pyruvate-derived nitrones to α,β-unsaturated aldehydes was investigated in the presence of various chiral amines. Highly functionalized isoxazolidines containing a quaternary stereocenter were obtained in moderate yields with up to 92% ee. To the best of our knowledge, this is the first example of an enantioselective 1,3-dipolar cycloaddition of ketonitrones. The model product was subsequently transformed into a 2-pyrrolidinone derivative in two steps.

Organocatalytic enantio- and diastereoselective 1,3-dipolar cycloaddition between alanine-derived ketonitrones and E-crotonaldehyde: Efficiency and full stereochemical studies

Highly enantio- and exo-selective 1,3-dipolar cycloadditions of alanine-derived ketonitrones to E-crotonaldehyde could be realized in a good yield by the use of a chiral imidazolidinone salt without the addition of water. The origin of the stereoselectivi