1373357-79-9Relevant academic research and scientific papers
Bifunctional organocatalytic strategy for inverse-electron-demand diels-alder reactions: Highly efficient in-situ substrate generation and activation to construct azaspirocyclic skeletons
Jiang, Xianxing,Shi, Xiaomei,Wang, Shoulei,Sun, Tao,Cao, Yiming,Wang, Rui
experimental part, p. 2084 - 2087 (2012/04/18)
Skeletons in the flask: The first highly enantioselective organocatalytic version of the title reaction using an in-situ substrate generation/activation catalytic mode is described (see scheme). The reaction provides an efficient enantioselective construction of functionalized azaspirocyclic skeletons. The in-situ generation of the enolate provides a new way in which to use this important nucleophile in organic synthesis. Copyright
