1373358-45-2Relevant academic research and scientific papers
Exploiting the addition of trimethyl(trifluoromethyl)silane to functionalized N-benzylimines for the preparation of two novel x-trifluoromethyl x-amino acids
Tkachenko, Anton N.,Radchenko, Dmytro S.,Mykhailiuk, Pavel K.,Shishkin, Oleg V.,Tolmachev, Andrei A.,Komarov, Igor V.
, p. 903 - 908 (2012)
Straightforward gram-scale syntheses of a novel γ-tri-fluoromethyl γ-amino acid and a novel ε-trifluoromethyl-ε-amino acid are described. The key step in both syntheses is an acid-catalyzed nucleophilic trifluoromethylation of a cyclic N-benzylimine possessing an ester group by using the Ruppert - Prakash reagent [trimethyl(trifluoromethyl)silane]. The strategy provides a potentially general approach for the synthesis of x-trifluoromethyl x-amino acids. Georg Thieme Verlag Stuttgart · New York.
