1373368-72-9Relevant academic research and scientific papers
COMPOUNDS AS MODULATORS OF TLR2 SIGNALING
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Paragraph 0258-0259; 0276, (2019/10/23)
The present disclosure relates to compounds, pharmaceutical compositions comprising such compounds, and use of such compounds in methods of treatment or in medicaments for treatment of inflammatory diseases and certain neurological disorders that are related to inflammatory signaling processes, including but not limited to misfolded proteins.
Modified shapiro reactions with bismesitylmagnesium as an efficient base reagent
Kerr, William J.,Morrison, Angus J.,Pazicky, Marek,Weber, Tina
, p. 2250 - 2253 (2012/06/30)
Bismesitylmagnesium has been shown to successfully mediate the Shapiro reaction. A range of tosylhydrazones has been subjected to the developed system, which furnishes exceptionally high incorporation of the introduced electrophiles and good yields of the functionalized styrenes. At conveniently accessible temperatures and with a comparably small excess of base reagent, this protocol offers an efficient alternative to the lithium-mediated process. Importantly, 1.05 equiv of Weinreb amides are sufficient to obtain aryl enones in good yields.
