1373391-59-3Relevant academic research and scientific papers
Discovery of 4′-azido-2′-deoxy-2′-C-methyl cytidine and prodrugs thereof: A potent inhibitor of Hepatitis C virus replication
Nilsson, Magnus,Kalayanov, Genadiy,Winqvist, Anna,Pinho, Pedro,Sund, Christian,Zhou, Xiao-Xiong,W?hling, Horst,Belfrage, Anna-Karin,Pelcman, Michael,Agback, Tatiana,Benckestock, Kurt,Wikstr?m, Kristina,Boothee, Mirva,Lindqvist, Anneli,Rydegrd, Christina,Jonckers, Tim H.M.,Vandyck, Koen,Raboisson, Pierre,Lin, Tse-I,Lachau-Durand, Sophie,De Kock, Herman,Smith, David B.,Martin, Joseph A.,Klumpp, Klaus,Simmen, Kenneth,Vrang, Lotta,Terelius, Ylva,Samuelsson, Bertil,Rosenquist, ?sa,Johansson, Nils Gunnar
, p. 3265 - 3268 (2012/06/29)
4′-Azido-2′-deoxy-2′-methylcytidine (14) is a potent nucleoside inhibitor of the HCV NS5B RNA-dependent RNA polymerase, displaying an EC50 value of 1.2 μM and showing moderate in vivo bioavailability in rat (F = 14%). Here we describe the synthesis and biological evaluation of 4′-azido-2′-deoxy-2′-methylcytidine and prodrug derivatives thereof.
