1373397-35-3Relevant academic research and scientific papers
1,2,3-Triazole fused with pyridine/pyrimidine as new template for antimicrobial agents: Regioselective synthesis and identification of potent N-heteroarenes
Marepu, Nagaraju,Yeturu, Sunandamma,Pal, Manojit
, p. 3302 - 3306 (2018/09/27)
The 1,2,3-triazole ring fused with pyridine/pyrimidine was explored as new template for the identification of potential antimicrobial agents. The regioselective synthesis of these pre-designed N-heteroarenes was achieved via exploring the application of Buchwald's strategy (i.e. C–N bond formation/reduction/diazotization/cyclization sequence) to the N-heteroarene system. Two of them showed promising antibacterial (comparable to streptomycin) and several showed potent antifungal (comparable to mancozeb) activities.
Synthetic studies pertaining to the 2,3-pyridyne and 4,5-pyrimidyne
Medina, Jose M.,Jackl, Moritz K.,Susick, Robert B.,Garg, Neil K.
, p. 3629 - 3634 (2016/06/06)
We report synthetic studies pertaining to two heterocyclic aryne intermediates: the 2,3-pyridyne and the 4,5-pyrimidyne. First, a 2,3-pyridyne precursor was readily accessed from 2-pyridone using a known procedure. Subsequently, 2,3-pyridyne generation an
Design and application of new imidazolylsulfonate-based benzyne precursor: An efficient triflate alternative
Kovacs, Szabolcs,Csincsi, Adam I.,Nagy, Tibor Zs.,Boros, Sandor,Timari, Geza,Novak, Zoltan
supporting information; experimental part, p. 2022 - 2025 (2012/06/16)
Several o-(trimethylsilyl)aryl imidazolylsulfonates were synthesized in a simple process and successfully applied in cycloadditions involving benzyne intermediates. The precursor offers an efficient alternative for generating benzynes compared to widely used ortho TMS triflates under similar reaction conditions. With the utilization of this new precursor, the formation of potentially genotoxic trifluoromethanesulfonate side product is eliminated. The applicability of the new benzyne precursor was demonstrated in different types of cycloaddition reactions to prepare heterocyclic molecules.
