13734-40-2

Basic information

• Product Name: Boc-O-tert-butyl-L-threonine
• Synonyms: N-ALPHA-T-BUTOXYCARBONYL-O-T-BUTYL-L-THREONINE;N-ALPHA-TERT-BUTYLOXYCARBONYL-O-TERT-BUTYL-L-THREONINE;N-ALPHA-T-BOC-O-T-BUTYL-L-THREONINE;BOC-O-T-BUTYL-L-THREONINE;BOC-O-TERT-BUTYL-L-THREONINE;BOC-L-THR(TBU)-OH;BOC-THREONINE(TBU)-OH;BOC-THR(BUT)-OH
• CAS NO: 13734-40-2
• Molecular Formula: C₁₃H₂₅NO₅
• Molecular Weight: 275.34
• Product Categories: Amino Acids;Threonine [Thr, T];Boc-Amino Acids and Derivative;Boc-Amino acid series
• Mol File: 13734-40-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 95-98 °C
• Boiling Point: 391.3 °C at 760 mmHg
• Flash Point: 190.4 °C
• Appearance: /Solid
• Density: 1.07 g/cm³
• Vapor Pressure: 3.27E-07mmHg at 25°C
• Refractive Index: 1.462
• Storage Temp.: 2-8°C
• Solubility: Soluble in DMF.
• PKA: 3.53±0.10(Predicted)
• BRN: 4454820
• CAS DataBase Reference: Boc-O-tert-butyl-L-threonine(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-O-tert-butyl-L-threonine(13734-40-2)
• EPA Substance Registry System: Boc-O-tert-butyl-L-threonine(13734-40-2)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 13734-40-2(Hazardous Substances Data)

Usage

Uses

N-Boc-O-tert-butyl-L-threonine is used as pharmaceutical intermediate.

General Description

Boc-Thr(t-Bu)-OH (N-Boc-O-tert-butyl-L-threonine) participates in the synthesis of 2,3-unsaturated glycosides, via reaction with per-O-acetylated glucal in the presence of Er(OTf)3 catalyst.

InChI:InChI=1/C13H25NO5/c1-8(18-12(2,3)4)9(10(15)16)14-11(17)19-13(5,6)7/h8-9H,1-7H3,(H,14,17)(H,15,16)/t8-,9+/m1/s1

Upstream product

• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 4378-13-6 (O-tert-butyl)-L-threonine 

Downstream Products

• 105224-67-7 2-[(R)-1-((2S,3R)-3-tert-Butoxy-2-tert-butoxycarbonylamino-butyrylamino)-2-phenyl-ethyl]-thiazole-4-carboxylic acid methyl ester 
• 1422970-01-1 tert-butyl ((2S,3R)-1-((3-bromophenyl)sulfonamido)-3-(tert-butoxy)-1-oxobutan-2-yl)carbamate 
• 1422970-00-0 tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamido)butan-2-yl)carbamate 
• 1422970-29-3 tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)hydrazinyl)butan-2-yl)carbamate 
• 1422970-08-8 tert-butyl ((2S,3R)-1-(2-(3-bromophenyl)hydrazinyl)-3-(tertbutoxy)-1-oxobutan-2-yl)carbamate 
• 1422970-06-6 (3-(((2S,3R)-3-(tert-butoxy)-2-((tert-butoxycarbonyl)amino)butanamido)methyl)phenyl)boronic acid 
• 1422970-31-7 C₂₈H₃₇N₃O₇S 
• 1432439-25-2 C₂₇H₃₆ClN₅O₅S 
• 1422970-14-6 C₁₉H₂₁N₃O₅S 
• 1422970-13-5 tert-butyl ((2S,3R)-1-(3-bromo-N-methylbenzenesulfonamido)-3-(tert-butoxy)-1-oxobutan-2-yl)carbamate 
• 1422970-30-6 tert-butyl ((2S,3R)-3-(tert-butoxy)-1-oxo-1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamido)butan-2-yl)carbamate 
• 1422970-11-3 tert-butyl ((2R,3R)-1-(3-bromobenzenesulfonamido)-3-(tertbutoxy)butan-2-yl)carbamate 
• 1422970-09-9 C₁₈H₁₉ClN₆O₂ 

Relevant articles and documents

Improved synthesis of etert-butyloxycarbonyl-amino acids through pH stable reactions

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